Transient Deformation of Neutrophils in Kawasaki Disease

Yumi Koike; Ryu Yanagisawa; Yoshifumi Ogiso; Yoshiaki Cho; Kisei Minami; Kouichi Takeuchi; Kazuo Sakashita; Tsukasa Higuchi

doi:10.1016/j.jpeds.2016.02.065

Transient Deformation of Neutrophils in Kawasaki Disease

J Pediatr. 2016 Jun:173:238-241.e1. doi: 10.1016/j.jpeds.2016.02.065. Epub 2016 Mar 30.

Authors

Yumi Koike¹, Ryu Yanagisawa², Yoshifumi Ogiso³, Yoshiaki Cho¹, Kisei Minami¹, Kouichi Takeuchi¹, Kazuo Sakashita⁴, Tsukasa Higuchi¹

Affiliations

¹ Department of General Pediatrics, Nagano Children's Hospital, Azumino, Japan.
² Department of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan; Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: [email protected].
³ Department of Clinical Pathology, Nagano Children's Hospital, Azumino, Japan.
⁴ Department of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan; Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

PMID: 27039225
DOI: 10.1016/j.jpeds.2016.02.065

Abstract

In the treatment of Kawasaki disease, resistance to high-dose immunoglobulin intravenous (IGIV) can occur. The neutrophil morphology analyses in 17 patients revealed that transient pseudo-Pelger-Huët anomaly was more frequently detected in the IGIV-resistant group. This finding may aid the prediction of IGIV resistance.

Keywords: Coronary artery lesion; High-dose intravenous immunoglobulin; Kawasaki disease; Mucocutaneous lymph node syndrome; Pseudo-Pelger‐Huët anomaly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
Drug Resistance*
Female
Humans
Immunoglobulins, Intravenous / therapeutic use*
Male
Mucocutaneous Lymph Node Syndrome / drug therapy*
Pelger-Huet Anomaly / complications
Pelger-Huet Anomaly / diagnosis*
Retrospective Studies

Substances

Immunoglobulins, Intravenous