Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study

J Cardiothorac Surg. 2016 Apr 5:11:43. doi: 10.1186/s13019-016-0437-8.

Abstract

Cardiac arrest with cerebral ischaemia frequently leads to severe neurological impairment. Extracorporeal life support (ECLS) has emerged as a valuable adjunct in resuscitation of cardiac arrest. Despite ECLS, the incidence of permanent neurological injury remains high. We hypothesize that patients receiving ECLS for cardiac arrest treated with therapeutic hypothermia at 34 °C have lower neurological complication rates compared to standard ECLS therapy at normothermia. Early results of this randomized study suggest that therapeutic hypothermia is safe in adult patients receiving ECLS, with similar complication rates as ECLS without hypothermia. Further studies are warranted to measure the efficacy of this therapy.

Keywords: Cardiac arrest; Extracorporeal life support; Therapeutic hypothermia.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiopulmonary Resuscitation*
  • Central Nervous System Diseases / etiology
  • Extracorporeal Membrane Oxygenation*
  • Female
  • Heart Arrest / complications
  • Heart Arrest / therapy*
  • Humans
  • Hypothermia, Induced* / adverse effects
  • Male
  • Middle Aged