Insulin Signaling in a Bit of a Jam

Vassily I Kutyavin; Ajay Chawla

doi:10.1016/j.cell.2016.03.012

Insulin Signaling in a Bit of a Jam

Cell. 2016 Apr 7;165(2):264-5. doi: 10.1016/j.cell.2016.03.012.

Authors

Vassily I Kutyavin¹, Ajay Chawla²

Affiliations

¹ Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
² Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA; Departments of Physiology and Medicine, University of California, San Francisco, San Francisco, CA 94158-9001, USA. Electronic address: [email protected].

PMID: 27058657
DOI: 10.1016/j.cell.2016.03.012

Abstract

In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.

Publication types

Comment

MeSH terms

Humans
Hyperglycemia / metabolism*
Inflammation / metabolism
Insulin*
Metabolic Diseases
Signal Transduction

Substances

Insulin

Abstract

Publication types

MeSH terms

Substances

Grants and funding