Neurotrophic factors and their inhibitors in chronic pain treatment

Jayne H Kelleher; Damini Tewari; Stephen B McMahon

doi:10.1016/j.nbd.2016.03.025

Neurotrophic factors and their inhibitors in chronic pain treatment

Neurobiol Dis. 2017 Jan;97(Pt B):127-138. doi: 10.1016/j.nbd.2016.03.025. Epub 2016 Apr 7.

Authors

Jayne H Kelleher¹, Damini Tewari², Stephen B McMahon²

Affiliations

¹ Neurorestoration group, King's College London, London, UK. Electronic address: [email protected].
² Neurorestoration group, King's College London, London, UK.

PMID: 27063668
DOI: 10.1016/j.nbd.2016.03.025

Abstract

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.

Keywords: Clinical trial; IL6; NGF; Pain.

Publication types

Review

MeSH terms

Animals
Chronic Pain / drug therapy*
Chronic Pain / metabolism*
Humans
Interleukin-6 / antagonists & inhibitors*
Interleukin-6 / metabolism*
Nerve Growth Factor / antagonists & inhibitors*
Nerve Growth Factor / metabolism*

Substances

Interleukin-6
Nerve Growth Factor