This first issue of Neurology® Genetics is out and it reflects very well the diversity of today's genetics. The approaches employed range from genome-wide association studies(1) to whole-exome sequencing (WES)(2-5) and targeted resequencing of a single gene.(6) One study examines the effects of disease-causing mutations on subcellular compartmentalization.(7) The disease phenotypes examined are just as diverse and include episodic disorders as well as diseases of the central and peripheral nervous systems.