Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China

Lianyan Xie; Jun Wu; Fangfang Zhang; Lizhong Han; Xiaokui Guo; Yuxing Ni; Jingyong Sun

doi:10.1128/AAC.00258-16

Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China

Antimicrob Agents Chemother. 2016 May 23;60(6):3849-53. doi: 10.1128/AAC.00258-16. Print 2016 Jun.

Authors

Lianyan Xie¹, Jun Wu², Fangfang Zhang¹, Lizhong Han¹, Xiaokui Guo³, Yuxing Ni¹, Jingyong Sun⁴

Affiliations

¹ Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
³ Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁴ Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China [email protected].

Abstract

We describe the genetic characteristics and possible transmission mechanism of blaPER in 25 clinical Gram-negative bacilli in Shanghai. blaPER, including blaPER-1, blaPER-3, and blaPER-4, was located chromosomally or in different plasmids. Tn1213 harboring blaPER-1 was first identified in two Proteus mirabilis isolates in China. The other blaPER variants were preceded by an ISCR1 element inside the complex class 1 integron associated with IS26, Tn21, Tn1696, and a miniature inverted-repeat transposable element.

MeSH terms

Acinetobacter Infections / epidemiology
Acinetobacter Infections / microbiology
Acinetobacter Infections / transmission
Acinetobacter baumannii / genetics*
Acinetobacter baumannii / isolation & purification
China / epidemiology
Chromosomes, Bacterial / chemistry
DNA Transposable Elements*
Gene Expression
Humans
Integrons
Molecular Epidemiology
Plasmids / chemistry
Plasmids / metabolism*
Proteus Infections / epidemiology
Proteus Infections / microbiology
Proteus Infections / transmission
Proteus mirabilis / genetics*
Proteus mirabilis / isolation & purification
Pseudomonas Infections / epidemiology
Pseudomonas Infections / microbiology
Pseudomonas Infections / transmission
Pseudomonas aeruginosa / genetics*
Pseudomonas aeruginosa / isolation & purification
Salmonella Infections / epidemiology
Salmonella Infections / microbiology
Salmonella Infections / transmission
Salmonella enterica / genetics*
Salmonella enterica / isolation & purification
beta-Lactamases / genetics*

Substances

DNA Transposable Elements
beta-Lactamases