Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation

Simon Favre; Amandine Rougeron; Laure Levoir; Baptiste Pérard; Noël Milpied; Isabelle Accoceberry; Frédéric Gabriel; Stéphane Vigouroux

doi:10.1016/j.mmcr.2016.03.001

Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation

Med Mycol Case Rep. 2016 Mar 8:11:21-3. doi: 10.1016/j.mmcr.2016.03.001. eCollection 2016 Mar.

Authors

Simon Favre¹, Amandine Rougeron², Laure Levoir³, Baptiste Pérard¹, Noël Milpied⁴, Isabelle Accoceberry², Frédéric Gabriel², Stéphane Vigouroux¹

Affiliations

¹ Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France.
² Laboratoire de Parasitologie Mycologie, CHU Pellegrin, Bordeaux, France.
³ Etablissement Français du Sang, Bordeaux, France.
⁴ Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France; Université Bordeaux Segalen, Bordeaux, France.

Abstract

We report a case of a 27-year old man with severe aplastic anemia who developed a Saprochaete clavata (Geotrichum clavatum) disseminated invasive infection shortly prior a scheduled allogeneic bone marrow transplantation. Treatment with a combination of voriconazole, liposomal amphotericin B and adjuvant granulocyte transfusions was successful before neutrophil recovery.

Keywords: Aplastic anemia; Hematological disease; Invasive infection; Saprochaete clavata.