A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed. Excellent regio- and stereocontrol have been achieved by means of the sequence of Hiyama and Heck cross-couplings. Undesirable homocoupling byproducts were avoided employing immobilized substrates.
Keywords: Heck coupling; Hiyama coupling; palladium cross-coupling reactions; solid-phase organic synthesis.