Abstract
Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Drug Carriers / chemistry
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Drug Delivery Systems
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Hydrogen-Ion Concentration
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Inflammation / drug therapy*
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Injections, Subcutaneous
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Microbial Sensitivity Tests
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Molecular Structure
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Nanostructures / chemistry*
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Polymers / chemistry
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects*
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Vancomycin / administration & dosage
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Vancomycin / chemistry
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Vancomycin / pharmacology*
Substances
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Anti-Bacterial Agents
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Drug Carriers
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Polymers
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Vancomycin