Osteoclast-Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine-Needle Aspiration Cytology With Histological and Immunohistochemical Findings

Diagn Cytopathol. 2016 Jun;44(6):548-51. doi: 10.1002/dc.23482. Epub 2016 Apr 15.

Abstract

Extraosseous giant cell tumors have been described in organs like larynx, thyroid, pancreas, heart, skin, lung, colon, kidney, and soft tissues (Wu et al., Oncol Lett 2013;6:829-832). Osteoclast-like giant cell tumor of the parotid gland has been reported only rarely with the first description of primary giant cell tumour of the parotid gland (GCTPs) given in 1984 by Eusebi et al. (Am J Clin Pathol. 1984;81:666-675). However, FNAC of osteoclast-like giant cell tumor of the parotid gland has not been well described, and only one case has been reported till date (Torabinezad et al., Acta Cytol. 2006;50:80-83). Two presentations have been observed in the form of either an isolated giant cell tumor (Eusebi et al., Am J Clin Pathol. 1984;81:666-675) or tumor associated with a carcinomatous component (Yang et al., Korean J Pathol 2012;46:297-301; Pasricha et al., J Can Res Ther 2013;9:314-316). GCTPs are uncommon benign soft tissue tumors with a malignant potential. Diagn. Cytopathol. 2016;44:548-551. © 2016 Wiley Periodicals, Inc.

Keywords: FNAC; histopathology; immunohistochemistry; primary giant cell tumor of parotid gland.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Female
  • Giant Cell Tumors / diagnostic imaging
  • Giant Cell Tumors / metabolism
  • Giant Cell Tumors / pathology*
  • Humans
  • Osteoclasts / pathology*
  • Parotid Neoplasms / diagnostic imaging
  • Parotid Neoplasms / metabolism
  • Parotid Neoplasms / pathology*

Substances

  • Biomarkers, Tumor