Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin

Nat Commun. 2016 Apr 19:7:11310. doi: 10.1038/ncomms11310.

Abstract

Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein 1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for genome stability and long-term transcriptional silencing. The mechanisms by which H3K9me3 and HP1 contribute to chromatin condensation have been speculative and controversial. Here we demonstrate that human HP1β is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. These are caused by dimeric and dynamic interaction with highly enriched H3K9me3 and are modulated by various electrostatic interfaces. HP1β bridges condensed chromatin, which we postulate stabilizes the compacted state. In agreement, HP1β genome-wide localization follows H3K9me3-enrichment and artificial bridging of chromatin fibres is sufficient for maintaining cellular heterochromatic conformation. Overall, our findings define a fundamental mechanism for chromatin higher order structural changes caused by HP1 proteins, which might contribute to the plastic nature of condensed chromatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Blotting, Western
  • Cell Line, Tumor
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone / chemistry
  • Chromosomal Proteins, Non-Histone / genetics
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Crystallography, X-Ray
  • Heterochromatin / genetics
  • Heterochromatin / metabolism*
  • Histones / chemistry
  • Histones / metabolism*
  • Humans
  • Kinetics
  • Lysine / chemistry
  • Lysine / metabolism*
  • Methylation
  • Microscopy, Fluorescence
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleosomes / chemistry
  • Nucleosomes / metabolism
  • Protein Binding
  • Protein Multimerization
  • Sequence Homology, Amino Acid
  • Static Electricity

Substances

  • CBX1 protein, human
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Heterochromatin
  • Histones
  • Nucleosomes
  • Chromobox Protein Homolog 5
  • Lysine

Associated data

  • GEO/GSE71114