Use of Postexposure Prophylaxis After Occupational Exposure to Zaire ebolavirus

Karen K Wong; Richard T Davey Jr; Angela L Hewlett; Colleen S Kraft; Aneesh K Mehta; Mark J Mulligan; Allison Beck; William Dorman; Christopher J Kratochvil; Lilin Lai; Tara N Palmore; Susan Rogers; Philip W Smith; Anthony F Suffredini; Mark Wolcott; Ute Ströher; Timothy M Uyeki

doi:10.1093/cid/ciw256

Use of Postexposure Prophylaxis After Occupational Exposure to Zaire ebolavirus

Clin Infect Dis. 2016 Aug 1;63(3):376-9. doi: 10.1093/cid/ciw256. Epub 2016 Apr 26.

Authors

Karen K Wong¹, Richard T Davey Jr², Angela L Hewlett³, Colleen S Kraft⁴, Aneesh K Mehta⁴, Mark J Mulligan⁴, Allison Beck⁴, William Dorman⁵, Christopher J Kratochvil³, Lilin Lai⁴, Tara N Palmore², Susan Rogers⁴, Philip W Smith³, Anthony F Suffredini⁶, Mark Wolcott⁵, Ute Ströher¹, Timothy M Uyeki¹

Affiliations

¹ Centers for Disease Control and Prevention.
² National Institute of Allergy and Infectious Diseases.
³ University of Nebraska Medical Center, Omaha.
⁴ Emory University, Atlanta, Georgia.
⁵ US Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
⁶ Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda.

Abstract

From September 2014 to April 2015, 6 persons who had occupational exposures to Zaire ebolavirus in West Africa received investigational agent rVSV-ZEBOV or TKM-100802 for postexposure prophylaxis and were monitored in the United States. All patients experienced self-limited symptoms after postexposure prophylaxis; none developed Ebola virus disease.

Keywords: Ebola virus; TKM-Ebola; postexposure prophylaxis; vesicular stomatitis virus.

Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Africa, Western
Ebolavirus / physiology*
Female
Hemorrhagic Fever, Ebola / diagnosis
Hemorrhagic Fever, Ebola / prevention & control*
Hemorrhagic Fever, Ebola / virology
Humans
Male
Middle Aged
Occupational Exposure*
Post-Exposure Prophylaxis
Retrospective Studies
United States

Grants and funding

UL1 TR000454/TR/NCATS NIH HHS/United States