Abstract
Not only has the use of tyrosine kinase inhibitors (TKI) for the treatment of metastatic renal cell carcinomas (mRCC) changed the therapeutic options for this disease significantly, but with the occurrence of typical side effects this therapy also poses a challenge for the treating physician. Fatigue und hypothyroidism are two common side effects of TKI therapy that can often appear simultaneously. By reducing the patients' quality of life these side effects often lead to a discontinuation of therapy. With this review we want to give the treating physician an overview of the classification and the specific treatment of TKI-induced fatigue and hypothyroidism in order to maximize patients' compliance and the therapeutic efficacy of TKI therapy.
Keywords:
Axitinib; Cabozantinib; Pazopanib; Sorafenib; Sunitinib.
MeSH terms
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Anilides / adverse effects
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Anilides / therapeutic use
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Axitinib
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Carcinoma, Renal Cell / drug therapy*
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Carcinoma, Renal Cell / pathology
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Disease Progression
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Enzyme Inhibitors / adverse effects*
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Enzyme Inhibitors / therapeutic use
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Fatigue / chemically induced*
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Fatigue / therapy
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Humans
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Hypothyroidism / chemically induced*
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Hypothyroidism / therapy
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Imidazoles / adverse effects
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Imidazoles / therapeutic use
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Indazoles / adverse effects
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Indazoles / therapeutic use
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Indoles / adverse effects
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Indoles / therapeutic use
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Kidney Neoplasms / drug therapy*
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Kidney Neoplasms / pathology
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Neoplasm Staging
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Niacinamide / adverse effects
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Niacinamide / analogs & derivatives
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Niacinamide / therapeutic use
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Phenylurea Compounds / adverse effects
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Phenylurea Compounds / therapeutic use
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Protein-Tyrosine Kinases / antagonists & inhibitors*
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Pyridines / adverse effects
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Pyridines / therapeutic use
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Pyrimidines / adverse effects
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Pyrimidines / therapeutic use
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Pyrroles / adverse effects
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Pyrroles / therapeutic use
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Quality of Life
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Sorafenib
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Sulfonamides / adverse effects
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Sulfonamides / therapeutic use
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Sunitinib
Substances
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Anilides
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Antineoplastic Agents
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Enzyme Inhibitors
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Imidazoles
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Indazoles
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Indoles
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Phenylurea Compounds
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Pyridines
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Pyrimidines
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Pyrroles
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Sulfonamides
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cabozantinib
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Niacinamide
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pazopanib
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Sorafenib
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Axitinib
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Protein-Tyrosine Kinases
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Sunitinib