Universal influenza vaccines: a realistic option?

R D de Vries; A F Altenburg; G F Rimmelzwaan

doi:10.1016/j.cmi.2015.12.005

Universal influenza vaccines: a realistic option?

Clin Microbiol Infect. 2016 Dec 1:22 Suppl 5:S120-S124. doi: 10.1016/j.cmi.2015.12.005. Epub 2016 Apr 26.

Authors

R D de Vries¹, A F Altenburg¹, G F Rimmelzwaan²

Affiliations

¹ Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
² Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: [email protected].

PMID: 27130671
DOI: 10.1016/j.cmi.2015.12.005

Abstract

The extensive antigenic drift displayed by seasonal influenza viruses and the risk of pandemics caused by newly emerging antigenically distinct influenza A viruses of novel subtypes has raised considerable interest in the development of so-called universal influenza vaccines. We review options for the development of universal flu vaccines and discuss progress that has been made recently.

Keywords: Antibodies; Immunity; Influenza; T lymphocytes; Universal vaccine; Virus vectors.

MeSH terms

Antibodies, Viral
Humans
Influenza A virus / classification
Influenza A virus / immunology*
Influenza Vaccines / immunology*
Influenza, Human / epidemiology
Influenza, Human / prevention & control*
Pandemics / prevention & control*
Seasons

Substances

Antibodies, Viral
Influenza Vaccines