iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation

Maureen McNulty; John D Crispino

doi:10.1016/j.stem.2016.04.007

iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation

Cell Stem Cell. 2016 May 5;18(5):563-4. doi: 10.1016/j.stem.2016.04.007.

Authors

Maureen McNulty¹, John D Crispino²

Affiliations

¹ Northwestern University, Division of Hematology/Oncology, 303 East Superior Street, Lurie 5-113, Chicago, IL 60611, USA.
² Northwestern University, Division of Hematology/Oncology, 303 East Superior Street, Lurie 5-113, Chicago, IL 60611, USA. Electronic address: [email protected].

PMID: 27152438
DOI: 10.1016/j.stem.2016.04.007

Abstract

GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.

Publication types

Comment

MeSH terms

Down Syndrome / genetics*
GATA1 Transcription Factor / genetics*
Humans
Induced Pluripotent Stem Cells
Mutation

Substances

GATA1 Transcription Factor