Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I

A Lake Wooten; Benjamin C Lewis; Daniel J Szatkowski; Deborah H Sultan; Kinda I Abdin; Thomas F Voller; Yongjian Liu; Suzanne E Lapi

doi:10.1016/j.apradiso.2016.04.025

Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I

Appl Radiat Isot. 2016 Jul:113:89-95. doi: 10.1016/j.apradiso.2016.04.025. Epub 2016 Apr 26.

Authors

A Lake Wooten¹, Benjamin C Lewis², Daniel J Szatkowski³, Deborah H Sultan⁴, Kinda I Abdin³, Thomas F Voller⁴, Yongjian Liu⁴, Suzanne E Lapi⁵

Affiliations

¹ Mallinckrodt Institute of Radiology, Washington University School of Medicine in Saint Louis, 4540 Parkview Place, Campus Box 8225, Saint Louis, MO 63110, United States; Department of Biomedical Engineering, Washington University in Saint Louis, Campus Box 1097, 1 Brookings Drive, Saint Louis, MO 63130, United States.
² Mallinckrodt Institute of Radiology, Washington University School of Medicine in Saint Louis, 4540 Parkview Place, Campus Box 8225, Saint Louis, MO 63110, United States; Department of Physics, Washington University in Saint Louis, United States.
³ Radiation Safety Office, Washington University in Saint Louis, Campus Box 8053, United States.
⁴ Mallinckrodt Institute of Radiology, Washington University School of Medicine in Saint Louis, 4540 Parkview Place, Campus Box 8225, Saint Louis, MO 63110, United States.
⁵ Mallinckrodt Institute of Radiology, Washington University School of Medicine in Saint Louis, 4540 Parkview Place, Campus Box 8225, Saint Louis, MO 63110, United States; Department of Biomedical Engineering, Washington University in Saint Louis, Campus Box 1097, 1 Brookings Drive, Saint Louis, MO 63130, United States; Department of Radiology, University of Alabama at Birmingham, Wallace Tumor Institute 310F, 1720 2nd Avenue South, Birmingham, AL 35294, United States. Electronic address: [email protected].

PMID: 27152914
DOI: 10.1016/j.apradiso.2016.04.025

Abstract

For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a "calibration setting number", but many recommended settings from manuals were interpolated based on standard sources of other radionuclide(s). We conducted HPGe gamma-ray spectroscopy, resulting in a reference for determining settings in two types of vessels containing one of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are recommended for different radionuclides and vessels.

Keywords: (124)I; (52)Mn; (64)Cu; (76)Br; (86)Y; (89)Zr; Calibration setting number; Dose calibrator; Instrumentation; Ionization chamber; Radiation measurements.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bromine Radioisotopes / analysis
Calibration
Copper Radioisotopes / analysis
Humans
Iodine Radioisotopes / analysis
Manganese / analysis
Positron-Emission Tomography / standards*
Positron-Emission Tomography / statistics & numerical data*
Radioisotopes / analysis*
Radiometry / standards*
Radiometry / statistics & numerical data*
Yttrium Radioisotopes / analysis
Zirconium / analysis

Substances

Bromine Radioisotopes
Bromine-76
Copper Radioisotopes
Copper-64
Iodine Radioisotopes
Iodine-124
Manganese-52
Radioisotopes
Yttrium Radioisotopes
Yttrium-86
Manganese
Zirconium
Zirconium-89

Grants and funding

1T32EB14855-01/NH/NIH HHS/United States