Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28

J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1268-1270. doi: 10.1136/jnnp-2016-313592. Epub 2016 May 6.
No abstract available

Keywords: ALS; GENETICS.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Amyotrophic Lateral Sclerosis
  • Canada
  • DNA Methylation
  • Humans
  • Italy / ethnology
  • Middle Aged
  • Mutation / genetics*
  • Rho Guanine Nucleotide Exchange Factors / genetics*
  • Superoxide Dismutase-1 / genetics*
  • Twins, Monozygotic / genetics*

Substances

  • ARHGEF3 protein, human
  • Rho Guanine Nucleotide Exchange Factors
  • SOD1 protein, human
  • Superoxide Dismutase-1