RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6

A M Api; D Belsito; S Bhatia; M Bruze; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; J F Lalko; A Lapczynski; D C Liebler; V T Politano; G Ritacco; D Salvito; T W Schultz; J Shen; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2016.04.027

RIFM fragrance ingredient safety assessment, benzyl isobutyrate, CAS Registry Number 103-28-6

Food Chem Toxicol. 2016 Nov:97S:S90-S100. doi: 10.1016/j.fct.2016.04.027. Epub 2016 May 5.

Authors

A M Api¹, D Belsito², S Bhatia³, M Bruze⁴, P Calow⁵, M L Dagli⁶, W Dekant⁷, A D Fryer⁸, L Kromidas³, S La Cava³, J F Lalko³, A Lapczynski³, D C Liebler⁹, V T Politano³, G Ritacco³, D Salvito³, T W Schultz¹⁰, J Shen³, I G Sipes¹¹, B Wall³, D K Wilcox³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: [email protected].
² Member RIFM Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
⁴ Member RIFM Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁵ Member RIFM Expert Panel, Humphrey School of Public Affairs, University of Minnesota, 301 19th Avenue South, Minneapolis, MN 55455, USA.
⁶ Member RIFM Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
⁷ Member RIFM Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
⁸ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
⁹ Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
¹⁰ Member RIFM Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996-4500, USA.
¹¹ Member RIFM Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.

PMID: 27156890
DOI: 10.1016/j.fct.2016.04.027

No abstract available

Keywords: Developmental and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization.

Publication types

Review

MeSH terms

Animals
Benzyl Compounds / chemistry
Benzyl Compounds / toxicity*
Consumer Product Safety
DNA Damage / drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Endpoint Determination
Isobutyrates / chemistry
Isobutyrates / toxicity*
No-Observed-Adverse-Effect Level
Perfume / chemistry
Perfume / toxicity*
Rats
Risk Assessment
Toxicity Tests / methods*

Substances

Benzyl Compounds
Isobutyrates
Perfume