Evaluation of wireless stimulation of the endocardium, WiSE, technology for treatment heart failure

Expert Rev Med Devices. 2016 Jun;13(6):523-31. doi: 10.1080/17434440.2016.1187559. Epub 2016 May 20.

Abstract

Introduction: There are several unsolved limitations in delivering cardiac resynchronization therapy. 30-40% of patients fail to have any clinical benefit after 6 months caused by different reasons.

Areas covered: Endocardial stimulation rather than conventional epicardial pacing has been shown to: be more physiologically, improve electrical stimulation of the left ventricular, give less dispersion of repolarisation and result in better resynchronization. The Wireless Cardiac Stimulation in Left Ventricle, WiCS-LV, system provides an option for wireless, left ventricular endocardial pacing triggered from a conventional right ventricular pacing spike from a co-implant. Expert commentary: The feasibility of the WiCS-LV system has been successfully demonstrated in a population of failed cardiac resynchronization patients, either failed implantation procedure of a conventional system, non-responder to conventional therapy or upgrade from pacemaker or defibrillator, where a conventional system was not an option. WiCS-LV is innovative technology with promising safety, performance and preliminary efficacy.

Keywords: Cardiac resynchronization therapy implantation; heart failure; leadless left ventricular endocardial pacing; ultrasound energy transfer.

Publication types

  • Review

MeSH terms

  • Cardiac Resynchronization Therapy / methods*
  • Cardiac Resynchronization Therapy Devices*
  • Endocardium / physiopathology*
  • Heart Failure / physiopathology*
  • Heart Failure / therapy*
  • Humans
  • Wireless Technology / instrumentation*