RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity

Cell Rep. 2016 May 17;15(7):1401-1411. doi: 10.1016/j.celrep.2016.04.033. Epub 2016 May 5.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. We, the authors, were made aware of irregularities associated in western blots shown in our article. We have further investigated the matter and found that the paper contains multiple examples of incorrect data use and image flipping in four figures, including the vertical flipping and reuse of the panel in Figures 1B and 3D, similar flipping and incorrect blot image in Figure 2C, and incorrect data use in Figure 4A. All of these figures were assembled by the corresponding author (O.B.) who takes full responsibility for the inaccuracies. Under these circumstances, we believe that the most responsible course of action is to retract the paper. We sincerely apologize to the scientific community for any inconvenience resulting from the publication and retraction of this manuscript.

Publication types

  • Retracted Publication

MeSH terms

  • Cell Cycle Checkpoints / drug effects
  • Cell Cycle Proteins / metabolism
  • Cell Nucleus / drug effects
  • Cell Nucleus / metabolism
  • Cellular Senescence / drug effects
  • Cellular Senescence / genetics*
  • Chromatin / metabolism
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • DNA Damage
  • DNA Repair / drug effects
  • DNA Replication / drug effects
  • Down-Regulation / drug effects
  • Fanconi Anemia Complementation Group D2 Protein / metabolism
  • Gene Silencing / drug effects
  • Genomic Instability* / drug effects
  • Humans
  • Mitomycin / pharmacology
  • Oncogenes
  • Protein Aggregates / drug effects
  • Protein Binding / drug effects
  • Stress, Physiological / drug effects
  • Tumor Suppressor Protein p53 / metabolism
  • Ubiquitin-Specific Proteases / metabolism*

Substances

  • Cell Cycle Proteins
  • Chromatin
  • Cyclin-Dependent Kinase Inhibitor p21
  • Fanconi Anemia Complementation Group D2 Protein
  • Protein Aggregates
  • Tumor Suppressor Protein p53
  • Mitomycin
  • USP1 protein, human
  • Ubiquitin-Specific Proteases