Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer

Katie L Hwang; Wolfram Goessling

doi:10.1007/978-3-319-30654-4_17

Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer

Adv Exp Med Biol. 2016:916:391-410. doi: 10.1007/978-3-319-30654-4_17.

Authors

Katie L Hwang^{1

2}, Wolfram Goessling^{3

4

5

6}

Affiliations

¹ Harvard Medical School, Medical Scientist Training Program, Boston, MA, USA.
² Genetics Division, Brigham and Women's Hospital, Boston, MA, USA.
³ Genetics Division, Brigham and Women's Hospital, Boston, MA, USA. [email protected].
⁴ Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA. [email protected].
⁵ Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected].
⁶ Harvard Stem Cell Institute, Cambridge, MA, Cambridge, MA, USA. [email protected].

PMID: 27165363
DOI: 10.1007/978-3-319-30654-4_17

Abstract

Liver and pancreatic cancers are amongst the leading causes of cancer death. In recent years, genetic and chemical approaches in zebrafish have elucidated cellular and molecular mechanisms of liver and pancreatic cancer formation and progression. In this chapter, we review the recent approaches and advances in the field to study both hepatocellular carcinomas and pancreatic cancer.

Keywords: Liver cancer; Liver development; Mutations; Pancreas cancer; Pancreas development; Transgenesis; Zebrafish.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Liver Neoplasms / chemically induced
Liver Neoplasms / genetics
Liver Neoplasms / pathology*
Pancreatic Neoplasms / genetics
Pancreatic Neoplasms / pathology*
Zebrafish

Abstract

Publication types

MeSH terms

Grants and funding