Head of the Class: OLIG2 and Glioblastoma Phenotype

Nalin Leelatian; Rebecca A Ihrie

doi:10.1016/j.ccell.2016.04.007

Head of the Class: OLIG2 and Glioblastoma Phenotype

Cancer Cell. 2016 May 9;29(5):613-615. doi: 10.1016/j.ccell.2016.04.007.

Authors

Nalin Leelatian¹, Rebecca A Ihrie²

Affiliations

¹ Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA.
² Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA; Department of Neurological Surgery, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA. Electronic address: [email protected].

PMID: 27165737
DOI: 10.1016/j.ccell.2016.04.007

Abstract

Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue of Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in glioblastoma upon ablation of Olig2.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain Neoplasms / genetics*
Glioblastoma / genetics*
Humans
Phenotype
Transcription Factors / genetics

Substances

Transcription Factors

Grants and funding

R01 NS096238/NS/NINDS NIH HHS/United States