Abstract
The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
MeSH terms
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Animals
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Boron Compounds / chemistry*
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Boron Compounds / pharmacokinetics
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Cell Line
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / pharmacokinetics
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Heart / drug effects*
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Humans
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MCF-7 Cells
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Membrane Potential, Mitochondrial / drug effects
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Microscopy, Confocal
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Molecular Structure
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Myocytes, Cardiac / drug effects*
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Myocytes, Cardiac / metabolism
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Rats
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Fluorescent Dyes