ERRγ-A New Player in β Cell Maturation

Jun Shirakawa; Rohit N Kulkarni

doi:10.1016/j.cmet.2016.04.026

ERRγ-A New Player in β Cell Maturation

Cell Metab. 2016 May 10;23(5):765-7. doi: 10.1016/j.cmet.2016.04.026.

Authors

Jun Shirakawa¹, Rohit N Kulkarni²

Affiliations

¹ Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
² Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: [email protected].

PMID: 27166940
DOI: 10.1016/j.cmet.2016.04.026

Abstract

Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells and human iPSC-derived β-like cells.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation* / genetics
Humans
Induced Pluripotent Stem Cells / metabolism
Insulin-Secreting Cells / cytology*
Insulin-Secreting Cells / metabolism*
Mice
Models, Biological
Receptors, Estrogen / metabolism*
Transcriptome / genetics

Substances

Receptors, Estrogen