Abstract
Immunohistochemistry was used to identify, enumerate, and describe the tissue distribution of Langerhans type (CD1a and CD207), myeloid (CD1c and CD141), and plasmacytoid (CD303 and CD304) dendritic cell subsets in oral mucosa of allergic and non-allergic individuals. Allergic individuals have more CD141+ myeloid cells in epithelium and more CD1a+ Langerhans cells in the lamina propria compared to healthy controls, but similar numbers for the other DC subtypes. Our data are the first to describe the presence of CD303+ plasmacytoid DCs in human oral mucosa and a dense intraepithelial network of CD141+ DCs. The number of Langerhans type DCs (CD1a and CD207) and myeloid DCs (CD1c), was higher in the oral mucosa than in the nasal mucosa of the same individual independent of the atopic status.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Case-Control Studies
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Cell Count
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Dendritic Cells / pathology*
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Female
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Healthy Volunteers*
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Humans
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Hypersensitivity / pathology*
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Immunohistochemistry
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Male
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Middle Aged
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Mouth Mucosa / pathology*
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Nasal Mucosa / pathology
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Young Adult
Grants and funding
WF and CvD have received private sector support for research and/or clinical trials related to treatment of allergic and non-allergic rhinitis by Allergopharma, ALK-Abello, GlaxoSmithKline, HAL Allergy, MSD, Optinose UK, and public sector research support by InterUniversity Attraction Poles (Belgium), ZonMW (The Netherlands), and Global Allergy and Asthma European Network (EU). SR, JvT, DvE, EdG declare no conflict of interests. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.