A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Jeffrey J Tosoian; Diane K Reyes; Michael A Gorin; Steven Hortopan; Alan W Partin; Kenneth J Pienta; Ashley E Ross; Edward M Schaeffer

doi:10.1016/j.eucr.2016.02.006

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Urol Case Rep. 2016 Mar 28:6:45-6. doi: 10.1016/j.eucr.2016.02.006. eCollection 2016 May.

Authors

Jeffrey J Tosoian¹, Diane K Reyes², Michael A Gorin¹, Steven Hortopan¹, Alan W Partin¹, Kenneth J Pienta², Ashley E Ross¹, Edward M Schaeffer³

Affiliations

¹ The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
³ Department of Urology, Northwestern University, Chicago, IL 60611, USA.

Abstract

The bone marrow microenvironment represents a "metastatic niche" in which prostate cancer cells may persist and evade cytotoxic therapy. In order to study the biology of prostate cancer dissemination, we have established a safe and efficient method for performing pubic bone marrow aspiration at the time of radical prostatectomy. We herein describe our experience with this technique.

Keywords: Bone; Metastasis; Prostate cancer.

Publication types

Case Reports

Grants and funding

P30 CA060553/CA/NCI NIH HHS/United States