Treponema pallidum Strain Types and Association with Macrolide Resistance in Sydney, Australia: New TP0548 Gene Types Identified

Phillip Read; Kaitlin A Tagg; Neisha Jeoffreys; Rebecca J Guy; Gwendolyn L Gilbert; Basil Donovan

doi:10.1128/JCM.00959-16

Treponema pallidum Strain Types and Association with Macrolide Resistance in Sydney, Australia: New TP0548 Gene Types Identified

J Clin Microbiol. 2016 Aug;54(8):2172-4. doi: 10.1128/JCM.00959-16. Epub 2016 May 18.

Authors

Phillip Read¹, Kaitlin A Tagg², Neisha Jeoffreys², Rebecca J Guy³, Gwendolyn L Gilbert², Basil Donovan⁴

Affiliations

¹ Kirketon Road Centre, South East Sydney Local Health District, Sydney, NSW, Australia The Kirby Institute, UNSW Australia, Sydney, NSW, Australia [email protected].
² Centre for Infectious Diseases and Microbiology-Public Health, Institute for Clinical Pathology and Medical Research, University of Sydney Western Clinical School, Westmead Hospital, Sydney, NSW, Australia.
³ The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.
⁴ The Kirby Institute, UNSW Australia, Sydney, NSW, Australia Sydney Sexual Health Centre, Sydney Hospital, Sydney, NSW, Australia.

Abstract

Strain typing of Treponema pallidum, using the three-target enhanced classification scheme, was performed with 191 samples obtained between 2004 and 2011 in Sydney, Australia. The most common strain type was 14d/g (92/191 samples [48%]). Two new TP0548 gene types were detected (m and n). Strain type was associated with macrolide resistance and possible acquisition outside Australia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Bacterial Agents / pharmacology*
Australia
Drug Resistance, Bacterial*
Female
Genotype*
Humans
Macrolides / pharmacology*
Male
Middle Aged
Molecular Typing*
Syphilis / microbiology*
Treponema pallidum / classification*
Treponema pallidum / drug effects
Treponema pallidum / isolation & purification
Young Adult

Substances

Anti-Bacterial Agents
Macrolides