Abstract
The effects of inhibition of ubiquinols and ubiquinones with various length of isoprenoid chain on the lipid peroxidation in membranes of brain mitochondria and synaptosomes were studied. The efficiency of inhibition effects of ubiquinols depends on the length of isoprenoid chain. Ubiquinols with shorter isoprenoid chains demonstrated more effective inhibition.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Brain / drug effects*
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Brain / metabolism
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Intracellular Membranes / drug effects*
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Intracellular Membranes / metabolism
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Lipid Peroxidation / drug effects*
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Membrane Lipids / metabolism*
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Rats
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Structure-Activity Relationship
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Synaptosomes / drug effects*
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Synaptosomes / metabolism
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Ubiquinone / analogs & derivatives*
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Ubiquinone / pharmacology
Substances
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Membrane Lipids
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Ubiquinone
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ubiquinol