Chemical-Induced Naive Pluripotency

Angela J Russell; Laurence Silpa

doi:10.1016/j.chembiol.2016.05.002

Chemical-Induced Naive Pluripotency

Cell Chem Biol. 2016 May 19;23(5):532-534. doi: 10.1016/j.chembiol.2016.05.002.

Authors

Angela J Russell¹, Laurence Silpa²

Affiliations

¹ Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: [email protected].
² Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

PMID: 27203371
DOI: 10.1016/j.chembiol.2016.05.002

Abstract

The capacity to harness the properties of pluripotent stem cells has a wide-reaching impact on regenerative medicine, drug discovery, and also basic science. Two recent publications by Ursu et al. and Illich et al. demonstrate that inhibition of a CK1 isoform efficiently induces naive pluripotency in epiblast stem cells.

Publication types

Comment

MeSH terms

Germ Layers*
Pluripotent Stem Cells*
Signal Transduction