Biomedical Applications of Terahertz Spectroscopy and Imaging

Trends Biotechnol. 2016 Oct;34(10):810-824. doi: 10.1016/j.tibtech.2016.04.008.

Abstract

Terahertz (THz=10(12)Hz) radiation has attracted wide attention for its unprecedented sensing ability and its noninvasive and nonionizing properties. Tremendous strides in THz instrumentation have prompted impressive breakthroughs in THz biomedical research. Here, we review the current state of THz spectroscopy and imaging in various biomedical applications ranging from biomolecules, including DNA/RNA, amino acids/peptides, proteins, and carbohydrates, to cells and tissues. We also address the potential biological effects of THz radiation during its biological applications and propose future prospects for this cutting-edge technology.

Keywords: THz; biological effect; biomedical research; imaging; spectroscopy; terahertz.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / analysis
  • Amino Acids / chemistry
  • Animals
  • Bacteria
  • Carbohydrates / analysis
  • Carbohydrates / chemistry
  • Cytological Techniques
  • DNA / analysis
  • DNA / chemistry
  • Diagnostic Imaging*
  • Humans
  • Mice
  • Proteins / analysis
  • Proteins / chemistry
  • Skin / diagnostic imaging
  • Terahertz Spectroscopy*

Substances

  • Amino Acids
  • Carbohydrates
  • Proteins
  • DNA