The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

Teresa Gil Carvalho; Belinda Morahan; Simona John von Freyend; Philippe Boeuf; Georges Grau; Jose Garcia-Bustos; Christian Doerig

doi:10.1016/j.molbiopara.2016.05.006

The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

Mol Biochem Parasitol. 2016 Jul;208(1):2-15. doi: 10.1016/j.molbiopara.2016.05.006. Epub 2016 May 17.

Authors

Teresa Gil Carvalho¹, Belinda Morahan¹, Simona John von Freyend¹, Philippe Boeuf², Georges Grau³, Jose Garcia-Bustos¹, Christian Doerig⁴

Affiliations

¹ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.
² Burnet Institute, Melbourne, Victoria 3004, Australia; The University of Melbourne, Department of Medicine, Melbourne, Victoria 3010, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria 3010, Australia.
³ Vascular Immunology Unit, Department of Pathology, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia.
⁴ Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: [email protected].

PMID: 27211241
DOI: 10.1016/j.molbiopara.2016.05.006

Abstract

Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.

Keywords: Malaria; Phosphorylation; Plasmodium; Protein kinase; Protein phosphatase; Signalling.

Publication types

Review

MeSH terms

Animals
Gene Expression Regulation*
Host-Pathogen Interactions*
Humans
Phosphorylation
Plasmodium / physiology*
Protein Processing, Post-Translational*
Protozoan Proteins / metabolism*
Signal Transduction*

Substances

Protozoan Proteins