Aromatase inhibitors and anti-synthetase syndrome

Int J Immunopathol Pharmacol. 2016 Sep;29(3):494-7. doi: 10.1177/0394632016651086. Epub 2016 May 25.

Abstract

Adjuvant therapy in postmenopausal women with endocrine-responsive breast cancer (BC) is actually centered on the use of anti-aromatase inhibitors (AI). Several reports, however, are emerging in literature associating the use of this drugs to rheumatic disorders. This case report describes the first case of anti-synthetase syndrome diagnosis after treatment with anti-estrogen agents in a patient with pre-existing rheumatoid arthritis.

Keywords: anti-synthetase syndrome; aromatase inhibitors; rheumatoid arthritis.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Aromatase Inhibitors / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / metabolism
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Chemotherapy, Adjuvant / methods
  • Female
  • Humans
  • Ligases / antagonists & inhibitors*
  • Middle Aged
  • Receptors, Estrogen / metabolism
  • Syndrome

Substances

  • Antineoplastic Agents, Hormonal
  • Aromatase Inhibitors
  • Receptors, Estrogen
  • Ligases