Computational insights into the origin of decrease/increase in potency of N-CDPCB analogues toward FTO

J Biomol Struct Dyn. 2017 Jun;35(8):1758-1765. doi: 10.1080/07391102.2016.1193445. Epub 2016 Jul 17.

Authors

Yan Qiao^{1

2}, Qinghua Yang³, Chuanjun Song³, Junbiao Chang¹

Affiliations

¹ a Department of Pathophysiology , Basic Medical College of Zhengzhou University , Zhengzhou 450001 , People's Republic of China.
² b Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy , East China University of Science & Technology , Shanghai 200237 , China.
³ c College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou 450001 , People's Republic of China.

PMID: 27227432
DOI: 10.1080/07391102.2016.1193445

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTO / antagonists & inhibitors
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / chemistry*
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism
Aminophenols / chemical synthesis
Aminophenols / chemistry*
Aminophenols / pharmacology
Anilides / chemical synthesis
Anilides / chemistry*
Anilides / pharmacology
Computational Biology*
Crystallography, X-Ray
Humans
Protein Conformation / drug effects

Substances

Aminophenols
Anilides
N-(5-chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
FTO protein, human