Accelerator-based production of the (99m)Tc-(186)Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)

Appl Radiat Isot. 2016 Aug:114:159-66. doi: 10.1016/j.apradiso.2016.05.024. Epub 2016 May 19.

Abstract

Novel, natural abundance metal disulfide targets were irradiated for 1h with a 10µA proton beam in a small, medical cyclotron. Osmium disulfide was synthesized by simple distillation and precipitation methods while MoS2 and WS2 were commercially available. The targets dissolved under mild conditions and were analyzed by γ-spectroscopy. Production rates and potential applications are discussed, including target recovery and recycling schemes for OsS2 and WS2.

Keywords: High specific activity (186)Re; High specific activity (99m)Tc; Metal disulfide targets; MoS(2); OsS(2); WS(2).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cyclotrons
  • Disulfides / radiation effects
  • Humans
  • Molybdenum / radiation effects
  • Osmium Compounds / radiation effects
  • Protons
  • Radioisotopes / isolation & purification*
  • Radiopharmaceuticals / isolation & purification
  • Rhenium / isolation & purification*
  • Spectrometry, Gamma
  • Technetium / isolation & purification*
  • Tungsten Compounds / radiation effects

Substances

  • Disulfides
  • Osmium Compounds
  • Protons
  • Radioisotopes
  • Radiopharmaceuticals
  • Rhenium-186
  • Tungsten Compounds
  • Rhenium
  • Technetium
  • Molybdenum
  • molybdenum disulfide