Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review

S Nanno; T Nakane; H Okamura; M Nishimoto; H Koh; H Nakamae; M Ohsawa; K Yarita; K Kamei; M Hino

doi:10.1111/tid.12561

Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review

Transpl Infect Dis. 2016 Aug;18(4):611-6. doi: 10.1111/tid.12561. Epub 2016 Aug 2.

Authors

S Nanno¹, T Nakane¹, H Okamura¹, M Nishimoto¹, H Koh¹, H Nakamae¹, M Ohsawa², K Yarita³, K Kamei³, M Hino¹

Affiliations

¹ Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
² Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
³ Medical Mycology Research Center, Chiba University, Chiba, Japan.

PMID: 27237466
DOI: 10.1111/tid.12561

Abstract

Disseminated infection by Hormographiella aspergillata is extremely rare and small intestine involvement has not been reported previously. A 51-year-old man with myelodysplastic syndrome developed pneumonia after cord blood cell transplantation. Fungal growth from the biopsied lung was identified as H. aspergillata by morphology and the gene analysis. Although antifungal agents including voriconazole and liposomal amphotericin B were administered, he died of disseminated H. aspergillata infection. We review the literature and discuss the treatment and prognosis.

Keywords: Hormographiella aspergillata; allogeneic hematopoietic stem cell transplantation.

Publication types

Case Reports
Review

MeSH terms

Agaricales / genetics
Agaricales / isolation & purification
Agaricales / pathogenicity*
Antifungal Agents / administration & dosage
Antifungal Agents / therapeutic use*
Brain / diagnostic imaging
Brain / pathology
Central Nervous System Fungal Infections / blood
Central Nervous System Fungal Infections / drug therapy
Central Nervous System Fungal Infections / etiology
Central Nervous System Fungal Infections / pathology
DNA, Fungal
Graft vs Host Disease / prevention & control
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Immunosuppression Therapy / adverse effects*
Immunosuppression Therapy / methods
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / therapeutic use
Intestinal Diseases / blood
Intestinal Diseases / drug therapy
Intestinal Diseases / etiology
Intestinal Diseases / pathology
Intestine, Small / pathology
Invasive Fungal Infections / blood
Invasive Fungal Infections / drug therapy
Invasive Fungal Infections / microbiology*
Lung Diseases, Fungal / blood
Lung Diseases, Fungal / drug therapy
Lung Diseases, Fungal / etiology
Lung Diseases, Fungal / pathology
Magnetic Resonance Imaging
Male
Middle Aged
Myelodysplastic Syndromes / surgery
Neutropenia / drug therapy
Neutropenia / etiology
Neutropenia / microbiology
Rare Diseases / blood
Rare Diseases / drug therapy
Rare Diseases / microbiology*
Sequence Analysis, DNA
Tomography, X-Ray Computed
Transplantation Conditioning / adverse effects
Transplantation Conditioning / methods
Transplantation, Homologous / adverse effects

Substances

Antifungal Agents
DNA, Fungal
Immunosuppressive Agents