Discovery of a gamma heavy chain disease in a patient followed-up for a lymphoplasma cell proliferative disorder

Ann Biol Clin (Paris). 2016 Jun 1;74(3):338-40. doi: 10.1684/abc.2016.1149.

Abstract

Gamma-heavy chains disease is a rare disease, with very few cases described in the literature. It is characterized by the presence of a monoclonal gamma-heavy chain without associated light chain. Its prevalence and prognosis are unknown. We report here the accidental discovery of a case of gamma-heavy chain disease during a pancytopenia exploration, performed in the hospital, in a patient known since 2002 for a lymphoplasmacytic type lymphoma first localized in bone marrow.

Keywords: heavy chain disease; immunotyping.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Delayed Diagnosis*
  • Heavy Chain Disease / complications*
  • Heavy Chain Disease / diagnosis*
  • Humans
  • Male
  • Monitoring, Physiologic
  • Waldenstrom Macroglobulinemia / complications*
  • Waldenstrom Macroglobulinemia / diagnosis
  • Waldenstrom Macroglobulinemia / therapy