Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

Xiao-Dong Zhang; Huasen Wang; Alexander L Antaris; Lulin Li; Shuo Diao; Rui Ma; Andy Nguyen; Guosong Hong; Zhuoran Ma; Joy Wang; Shoujun Zhu; Joseph M Castellano; Tony Wyss-Coray; Yongye Liang; Jian Luo; Hongjie Dai

doi:10.1002/adma.201600706

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore

Adv Mater. 2016 Aug;28(32):6872-9. doi: 10.1002/adma.201600706. Epub 2016 Jun 2.

Authors

Xiao-Dong Zhang^{1

2}, Huasen Wang³, Alexander L Antaris¹, Lulin Li⁴, Shuo Diao¹, Rui Ma³, Andy Nguyen⁴, Guosong Hong¹, Zhuoran Ma¹, Joy Wang¹, Shoujun Zhu¹, Joseph M Castellano⁵, Tony Wyss-Coray^{5

6}, Yongye Liang³, Jian Luo^{5

4}, Hongjie Dai¹

Affiliations

¹ Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
² Department of Physics, School of Science, Tianjin University, Tianjin, 300354, P. R. China.
³ Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
⁴ Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
⁵ Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
⁶ Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

Keywords: molecular fluorophores; near-infrared II fluorescence imaging; traumatic brain injury.

MeSH terms

Animals
Brain Injuries, Traumatic / diagnostic imaging*
Disease Models, Animal
Fluorescent Dyes / analysis*
Mice

Substances

Fluorescent Dyes

Abstract

MeSH terms

Substances

Grants and funding