Leishmania DNA Replication Timing: A Stochastic Event?

Maria C Rocha-Granados; Michele M Klingbeil

doi:10.1016/j.pt.2016.05.011

Leishmania DNA Replication Timing: A Stochastic Event?

Trends Parasitol. 2016 Oct;32(10):755-757. doi: 10.1016/j.pt.2016.05.011. Epub 2016 May 30.

Authors

Maria C Rocha-Granados¹, Michele M Klingbeil²

Affiliations

¹ Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
² Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: [email protected].

PMID: 27255527
DOI: 10.1016/j.pt.2016.05.011

Abstract

For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.

Keywords: DNA replication; Leishmania; aneuploidy; origin of replication; stochastic timing.

Publication types

Comment

MeSH terms

Animals
DNA Replication Timing*
Drug Delivery Systems
Genomic Instability*
Humans
Leishmania / genetics*
Leishmaniasis / parasitology
Leishmaniasis / prevention & control
Replication Origin / genetics

Grants and funding

R21 AI126455/AI/NIAID NIH HHS/United States