Inference of Ancestry in Forensic Analysis II: Analysis of Genetic Data

Carla Santos; Chris Phillips; A Gomez-Tato; J Alvarez-Dios; Ángel Carracedo; Maria Victoria Lareu

doi:10.1007/978-1-4939-3597-0_19

Inference of Ancestry in Forensic Analysis II: Analysis of Genetic Data

Methods Mol Biol. 2016:1420:255-85. doi: 10.1007/978-1-4939-3597-0_19.

Authors

Carla Santos¹, Chris Phillips², A Gomez-Tato³, J Alvarez-Dios³, Ángel Carracedo^{2

4}, Maria Victoria Lareu²

Affiliations

¹ Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain. [email protected].
² Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain.
³ Faculty of Mathematics, University of Santiago de Compostela, Galicia, Spain.
⁴ Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

PMID: 27259745
DOI: 10.1007/978-1-4939-3597-0_19

Abstract

Three approaches applicable to the analysis of forensic ancestry-informative marker data-STRUCTURE, principal component analysis, and the Snipper Bayesian classification system-are reviewed. Detailed step-by-step guidance is provided for adjusting parameter settings in STRUCTURE with particular regard to their effect when differentiating populations. Several enhancements to the Snipper online forensic classification portal are described, highlighting the added functionality they bring to particular aspects of ancestry-informative SNP analysis in a forensic context.

Keywords: Bayesian methods; Genetic ancestry; PCA; Reference data; SPSmart browser; STRUCTURE; Snipper.

MeSH terms

Forensic Genetics / methods*
Genetics, Population
Humans
Internet
Polymorphism, Single Nucleotide
Software