Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer

Miho Shiomi; Shinichiro Mori; Makoto Shinoto; Yuko Nakayama; Tadashi Kamada; Shigeru Yamada

doi:10.1016/j.radonc.2016.04.026

Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer

Radiother Oncol. 2016 May;119(2):326-30. doi: 10.1016/j.radonc.2016.04.026. Epub 2016 Jun 1.

Authors

Miho Shiomi¹, Shinichiro Mori², Makoto Shinoto³, Yuko Nakayama⁴, Tadashi Kamada¹, Shigeru Yamada⁵

Affiliations

¹ Research Center for Charged Particle Therapy, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; Department of Radiation Oncology, Graduate School of Medicine, Chiba University, Japan.
² Research Center for Charged Particle Therapy, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.
³ Ion-Beam Therapy Center, SAGA HIMAT Foundation, Japan.
⁴ Ion-beam Radiation Oncology Center in Kanagawa, Kanagawa Cancer Center, Japan.
⁵ Research Center for Charged Particle Therapy, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; Department of Radiation Oncology, Graduate School of Medicine, Chiba University, Japan. Electronic address: [email protected].

PMID: 27262617
DOI: 10.1016/j.radonc.2016.04.026

Abstract

Purpose: To compare carbon-ion beam dose distribution between passive and scanning radiation therapies for locally advanced pancreatic cancer.

Materials and methods: Thirteen pancreatic cancer patients were included in this study. Four types of treatment planning with respiratory gating were calculated for each patient: a four-field box with passive irradiation (Plan 1), scanning irradiation (Plan 2), a three-field (150°, 180° and 210°) protocol with passive irradiation (Plan 3), and scanning irradiation (Plan 4). The irradiation plans each delivered 55.2Gy (RBE) to the planning target volume (PTV) and were compared with respect to doses to the PTV and organs at risk (OARs).

Results: Plan 3 exceeded the dose assessment metrics to the spinal cord. Scanning irradiation plans (Plan 2 and, particularly, Plan 4) offered significantly reduced dosage to the stomach and the duodenum compared with passive irradiation.

Conclusion: Three-field oblique scanning irradiation for pancreatic cancer has the potential to reduce gastrointestinal exposure and influence of peristalsis on dose distribution.

Keywords: Carbon-ion radiotherapy; Pancreatic cancer; Radiation dosimetry.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Aged, 80 and over
Female
Heavy Ion Radiotherapy / methods*
Humans
Male
Middle Aged
Organs at Risk / radiation effects
Pancreatic Neoplasms / radiotherapy*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods
Radiotherapy, Intensity-Modulated / methods*
Treatment Outcome