MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer

Bull Exp Biol Med. 2016 May;161(1):112-5. doi: 10.1007/s10517-016-3358-6. Epub 2016 Jun 6.

Abstract

We analyzed microRNA profile in hemolysis-free blood plasma of patients with prostatic cancer. The metastatic form of prostatic cancer was found to be associated with increased levels of hsa-miR-22-3p, hsa-miR-663a, and hsa-miR-4674 in comparison with non-metastatic form. Common candidate target genes of these microRNA include JUNB, KMT2A, and XPO6.

Keywords: blood plasma; metastases; microRNA; microarray analysis; prostatic cancer.

MeSH terms

  • Biomarkers, Tumor / blood*
  • Case-Control Studies
  • Hemolysis
  • Humans
  • Male
  • MicroRNAs / blood*
  • Neoplasm Metastasis
  • Prostatic Neoplasms, Castration-Resistant / blood*
  • Prostatic Neoplasms, Castration-Resistant / pathology

Substances

  • Biomarkers, Tumor
  • MIRN4674 microRNA, human
  • MicroRNAs