High soluble IL-7 receptor expression in Sjögren's syndrome identifies patients with increased immunopathology and dryness

Ann Rheum Dis. 2016 Sep;75(9):1735-6. doi: 10.1136/annrheumdis-2016-209236. Epub 2016 Jun 7.

Authors

M R Hillen¹, S L M Blokland¹, A P Risselada², A Bikker², B R Lauwerys³, A A Kruize², T R D J Radstake¹, J A G van Roon¹

Affiliations

¹ Department of Rheumatology & Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.
² Department of Rheumatology & Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.
³ Department of Rheumatology, Catholic University Louvain, Louvain, Belgium.

PMID: 27269297
DOI: 10.1136/annrheumdis-2016-209236

No abstract available

Keywords: Autoantibodies; Autoimmune Diseases; Cytokines; Sjøgren's Syndrome.

Publication types

Comparative Study
Letter

MeSH terms

Adult
Aged
Animals
Autoantibodies / blood
Autoantibodies / immunology*
Biopsy, Needle
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation*
Humans
Immunohistochemistry
Male
Middle Aged
Receptors, Interleukin-7 / genetics*
Receptors, Interleukin-7 / metabolism
Reference Values
Retrospective Studies
Severity of Illness Index
Sjogren's Syndrome / genetics*
Sjogren's Syndrome / immunology
Sjogren's Syndrome / pathology*
Solubility
Statistics, Nonparametric
Young Adult

Substances

Autoantibodies
Receptors, Interleukin-7