Cell Composition of Central and Peripheral Lymphoid Organs of Wistar Rats Treated with a Biomedical Cell Product

Bull Exp Biol Med. 2016 May;161(1):150-4. doi: 10.1007/s10517-016-3366-6. Epub 2016 Jun 6.

Abstract

We studied the effect of a biomedical cell product (bone marrow multipotent mesenchymal stromal cells and products secreted by these cells in conditioned medium) on subpopulation composition of lymphoid cells of central and peripheral lymphoid organs of Wistar rats under normal conditions. Changes in the subpopulation composition of lymphoid organs depended on the route of administration of biomedical cell product.

Keywords: biomedical cell product; conditioned medium; multipotent mesenchymal stromal cells; subpopulations.

MeSH terms

  • Administration, Intravenous
  • Animals
  • Cells, Cultured
  • Culture Media, Conditioned
  • Female
  • Lymph Nodes / cytology*
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / metabolism
  • Rats, Wistar
  • Spleen / cytology*
  • Thymus Gland / cytology*

Substances

  • Culture Media, Conditioned