Platelet-enriched plasma (PRP) contains high concentration of platelets and abundant growth factors, which is made by centrifuging of blood and separating of blood elements. PRP promotes tendon repair by releasing various cytokines to enhance cell proliferation, tenogenic differentiation, formation and secretion of matrix; meantime, it can reduce pain by inhibiting the expression of pain-associated molecules. A number of clinical studies demonstrated that PRP was effective in treatment of tendinopathy, including patellar tendinopathy, lateral epicondylitis and plantar fasciopathy. However, some studies did not support this conclusion, because of disparity of PRP types, therapeutic courses and injections protocols in clinical application. Based on its safety, PRP can be a choice of treatment for tendinopathy, in case other non-surgical therapies are of no effect.
血小板富集血浆(PRP)是血小板浓度高于体内正常浓度且富含各种生长因子的血浆制品,通过全血离心去除红细胞后获得。PRP通过释放丰富的细胞因子,促进肌腱细胞及肌腱干细胞增殖、分化及基质的合成分泌,从而促进组织修复和再生。同时,通过抑制疼痛相关因子的表达,缓解患者的疼痛症状。目前大量临床研究表明,PRP对于髌腱病、肱骨外上髁炎、足底筋膜炎等肌腱疾病有着较好的修复作用,但也有一些研究显示其效果不确切,主要是由于PRP提取流程不一致、患者病程不同以及注射方案不同等所导致。因其安全,可作为肌腱病保守治疗的选择,尤其是在其他保守治疗无效的情况。相信通过更多严谨的基础研究及临床试验,规范其使用过程,PRP将在肌腱病的治疗上发挥更重要的作用。