Abstract
Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence. Most patients showed good response to antimalarials, topical steroids, or systemic steroids.
MeSH terms
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Antibodies, Antinuclear / blood*
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Antimalarials / administration & dosage
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Antimalarials / adverse effects
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Female
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Glucocorticoids / administration & dosage*
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Humans
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Hydroxychloroquine / administration & dosage
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Hydroxychloroquine / adverse effects
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Lupus Erythematosus, Discoid* / blood
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Lupus Erythematosus, Discoid* / complications
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Lupus Erythematosus, Discoid* / pathology
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Lupus Erythematosus, Discoid* / therapy
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Middle Aged
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Neck
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Ribonucleoproteins / blood*
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Scleroderma, Localized* / blood
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Scleroderma, Localized* / complications
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Scleroderma, Localized* / pathology
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Scleroderma, Localized* / therapy
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Skin / pathology*
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Syndrome
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Treatment Outcome
Substances
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Antibodies, Antinuclear
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Antimalarials
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Glucocorticoids
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Ribonucleoproteins
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SS-A antigen
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Hydroxychloroquine