A Light-Induced Vinylogous Nazarov-Type Cyclization

Org Lett. 2016 Jul 1;18(13):3043-5. doi: 10.1021/acs.orglett.6b01449. Epub 2016 Jun 9.

Abstract

The first examples of a photochemically induced vinylogous Nazarov-type cyclization forming a cycloheptadienone core are described. The reaction can be included in a three-step cascade consisting of a photochemical isoxazole-azirine ring contraction, cobalt(II)-catalyzed ring expansion, and the photochemical cyclization. Furthermore, the first representative of the hitherto unknown 1-azatricyclo[2.2.0.0(2,6)]hexanes has been identified as a side product of the azirine formation.

Publication types

  • Research Support, Non-U.S. Gov't