Multifocal Lymphangioendotheliomatosis with Thrombocytopenia: Presentation of Two Cases Treated with Sirolimus

Pediatr Dermatol. 2016 Jul;33(4):e235-9. doi: 10.1111/pde.12879. Epub 2016 Jun 10.

Abstract

Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a rare disease characterized by congenital and progressive vascular lesions of the skin and gastrointestinal tract that may be associated with thrombocytopenia and possibly life-threatening gastrointestinal bleeding. Reports published on the disease and treatment strategies are scarce. We present two cases of MLT treated with sirolimus.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antineoplastic / therapeutic use*
  • Female
  • Gastrointestinal Hemorrhage / etiology
  • Humans
  • Infant
  • Lymphangioma / complications
  • Lymphangioma / drug therapy*
  • Sirolimus / therapeutic use*
  • Skin / pathology
  • Skin Neoplasms / complications
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology*
  • Thrombocytopenia / complications
  • Thrombocytopenia / drug therapy*

Substances

  • Antibiotics, Antineoplastic
  • Sirolimus