A Cap for Every Occasion: Alternative eIF4F Complexes

Trends Biochem Sci. 2016 Oct;41(10):821-823. doi: 10.1016/j.tibs.2016.05.009. Epub 2016 Jun 6.

Abstract

The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5' cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

Keywords: eIF4E; eIF4E2; eIF4F; eIF4G3; hypoxia; translation.

Publication types

  • Review

MeSH terms

  • Animals
  • Eukaryotic Initiation Factor-4E / genetics*
  • Eukaryotic Initiation Factor-4E / metabolism
  • Eukaryotic Initiation Factor-4F / genetics*
  • Eukaryotic Initiation Factor-4F / metabolism
  • Humans
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Protein Binding
  • Protein Biosynthesis*
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • RNA Caps / genetics
  • RNA Caps / metabolism
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces / metabolism
  • Trypanosomatina / genetics*
  • Trypanosomatina / metabolism

Substances

  • Eukaryotic Initiation Factor-4E
  • Eukaryotic Initiation Factor-4F
  • Phosphoproteins
  • Protein Isoforms
  • RNA Caps
  • RNA, Messenger