Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis

Antimicrob Agents Chemother. 1989 Apr;33(4):573-5. doi: 10.1128/AAC.33.4.573.

Abstract

ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antifungal Agents / pharmacokinetics
  • Antifungal Agents / therapeutic use*
  • Blastomyces / drug effects
  • Blastomycosis / drug therapy*
  • Blastomycosis / microbiology
  • Ketoconazole / therapeutic use*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Time Factors
  • Triazoles / pharmacokinetics
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Triazoles
  • ICI 195739
  • Ketoconazole