[Reassessment of second-look operations (SLO) in the treatment of ovarian cancer]

Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-2):1303-9.
[Article in Japanese]

Abstract

To reassess the role off SLO in the ovarian cancer, 96 patients who underwent second laparotomy from 1968 to 1987 in our department were studied. 59 out of 96 (60.5%) were completed primary surgery while rest of them (39.5%) were incompletely resected. SLO was carried out in 34 patients of former group (57.6%) and in 9 patients in later group (24.3%). Recurrence was found in 3 patients of complete primary surgery + SLO (group A) whereas 5 patients of incomplete primary surgery + SLO (group C). Recurrence rate was significantly lower in group A. There was no relationship between the site of recurrence and survival time. Until we obtain a good tool to detect recurrence site, SLO has an important role for the management of patients. Combination of radical debulking surgery and CAP regimen with 70 mg/m2 of CDDP at least for 2 years with SLO is considered to be important to improve prognosis and quality of life of ovarian cancer patients.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Recurrence, Local / surgery
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / surgery*
  • Peritoneal Neoplasms / drug therapy
  • Peritoneal Neoplasms / secondary
  • Peritoneal Neoplasms / surgery
  • Prognosis
  • Recurrence
  • Reoperation

Substances

  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin

Supplementary concepts

  • CISCA protocol